Transfersomes: A Novel Vesicular Carrier for Enhanced Transdermal Delivery of Sertraline: Development, Characterization, and Performance Evaluation
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چکیده
منابع مشابه
Transfersomes: A Novel Vesicular Carrier for Enhanced Transdermal Delivery of Sertraline: Development, Characterization, and Performance Evaluation
The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic surfactant (span 80), soya lecithin, and carbopol 940 by the rotary evaporation sonication method. The prepared formulations w...
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The aim of this study was to enhance the transdermal delivery of Sildenafil Citrate by encapsulation in nano sized ultra deformable vesicles, transfersomes. The thin film hydration and sonication technique was utilized in the preparation of Sildenafil Citrate loaded Transfersomes and both non ionic and ionic edge activators (anionic and cationic) were used in varying ratios to study their effec...
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Ethosomes are ethanolic liposomes, a novel lipid vesicular carrier prepared using phospholipid, ethanol and water. Instead of rupturing the liposomal structure while increasing the ethanol concentration, vesicles superior in delivering the active ingredient into the deeper layers of the skin was obtained, named as ethosomes. In contrast to the liposomes and deformable liposomes, ethosomes have ...
متن کاملTransdermal Drug Delivery through Carriers: Transfersomes
Delivery of drug through Transdermal route represents a most convenient and novel approach. Transfersomes were found to be more effective as they render controlled release of drug due to depot formation in skin and were more effective in transdermal delivery. Transfersomes are applied to the skin and permeate through the stratum corneum lipid lamellar regions as a result of the hydration and os...
متن کاملIn vivo microdialysis for the evaluation of transfersomes as a novel transdermal delivery vehicle for cinnamic acid.
In this study, cinnamic acid-loaded transfersomes were prepared and dermal microdialysis sampling was used in Sprague-Dawley rats to compare the amount of drug released into the skin using transfersomes as transdermal carriers with that released on using conventional liposomes. The formulation of cinnamic acid-loaded transfersomes was optimized by a uniform design through in vitro transdermal p...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2012
ISSN: 0036-8709,2218-0532
DOI: 10.3797/scipharm.1208-02